1. Profiling Allosteric Modulators of CB₁R with an Allosteric Fluoroprobe 

   Kosar, Miroslav; Perera, Themiya; Ganzoni, Rudolf L. Z.; et al. (2025)

   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

   Allosteric modulation of cannabinoid receptor type 1 (CB1R) offers a promising alternative to conventional therapeutic approaches using orthosteric ligands (OLs). Currently, CB1R allosteric modulators (AMs) are characterized based on their ability to modulate binding or functional response of OLs, preventing isolation of individual contributions by allosteric and orthosteric ligands. Herein, we develop the first allosteric fluoroprobe and ...

   Journal Article

2. A Genome-Wide Association Study Identifies Markers and Candidate Genes Affecting Tolerance to the Wheat Pathogen <i>Zymoseptoria tritici</i> 

   Mikaberidze, Alexey; McDonald, Bruce A.; Kronenberg, Lukas (2025)

   Molecular Plant-Microbe Interactions

   Plants defend themselves against pathogens using either resistance, measured as the host's ability to limit pathogen multiplication, or tolerance, measured as the host's ability to reduce the negative effects of infection. Tolerance is a promising trait for crop breeding, but its genetic basis has rarely been studied and remains poorly understood. Here, we reveal the genetic basis of leaf tolerance to the fungal pathogen Zymoseptoria ...

   Journal Article

3. Coherent Multidimensional Spectroscopy Reveals Hot Exciton Cooling Landscapes in CsPbBr₃ Quantum Dots 

   Ghosh, Arnab; Perez, Carlos Mora; Brosseau, Patrick; et al. (2025)

   ACS Nano

   Hot exciton relaxation dynamics is one of the main processes in quantum dots (QD), conferring their functions in optoelectronic devices spanning photovoltaics and solar fuel generation to light emitting diodes, lasers, and quantum light sources. The challenge has been to monitor energy relaxation dynamics in parallel with resolution of excitation or excess energy. Here, we exploit the unique capacity of Coherent Multi-Dimensional Spectroscopy ...

   Journal Article

4. Replicating community dynamics reveals how initial composition shapes the functional outcomes of bacterial communities 

   Pascual-Garcia, A.; Rivett, D. W.; Jones, Matt Lloyd; et al. (2025)

   NATURE COMMUNICATIONS

   Bacterial communities play key roles in global biogeochemical cycles, industry, agriculture, human health, and animal husbandry. There is therefore great interest in understanding bacterial community dynamics so that they can be controlled and engineered to optimise ecosystem services. We assess the reproducibility and predictability of bacterial community dynamics by creating a frozen archive of hundreds of naturally-occurring bacterial ...

   Journal Article

5. Uniqueness on average of large isoperimetric sets in noncompact manifolds with nonnegative Ricci curvature 

   Antonelli, Gioacchino; Pozzetta, Marco; Semola, Daniele (2025)

   COMMUNICATIONS ON PURE AND APPLIED MATHEMATICS

   Let (M-n,g) be a complete Riemannian manifold which is not isometric to Rn, has nonnegative Ricci curvature, Euclidean volume growth, and quadratic Riemann curvature decay. We prove that there exists a set G subset of(0,infinity) with density 1 at infinity such that for every V is an element of G there is a unique isoperimetric set of volume V in M; moreover, its boundary is strictly volume preserving stable.<br /> The latter result cannot ...

   Journal Article

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